Ambrisentan 5 mg + Tadalafil 20 mg Kit
Ambrisentan 5 mg + Tadalafil 20 mg Kit
Ambrisentan 5 mg + Tadalafil 20 mg — PCD Pharma Franchise, Wholesale Supply & Third Party Manufacturing
Form: Kit
Class: Fixed-Dose Combination — Endothelin receptor antagonist + PDE-5 inhibitor
✓ Pan-India Monopoly PCD
✓ Available Now
Pricing, brochure & monopoly territory within 24 hrs.
Ambrisentan 5 mg + Tadalafil 20 mg Kit is manufactured and supplied by Trumac Healthcare, a WHO-GMP certified pharmaceutical company in India. This kit is available for monopoly PCD pharma franchise, wholesale and distributor supply, and third party / contract manufacturing across all Indian states.
Therapeutic Indications
- Pulmonary arterial hypertension (WHO Group 1) to improve exercise capacity
- Initial combination with tadalafil to delay disease progression in PAH
- Initial combination therapy with ambrisentan in PAH
Mechanism of Action
Ambrisentan — Ambrisentan selectively blocks endothelin type A receptors on pulmonary vascular smooth muscle. This counters endothelin-1-driven vasoconstriction and vessel wall thickening, lowering pulmonary vascular resistance and improving exercise capacity.
Tadalafil — Tadalafil inhibits phosphodiesterase-5, the enzyme that breaks down cyclic GMP in the smooth muscle of pulmonary blood vessels. Higher cyclic GMP relaxes these vessels and lowers pulmonary pressure, complementing the endothelin blockade of ambrisentan.
Combining these ingredients in one kit provides complementary action on the target condition and simplifies therapy compared with taking the components separately.
Dosage & Administration
- Dosage of Ambrisentan 5 mg + Tadalafil 20 mg Kit must be individualised by the treating physician according to the patient's age, body weight, indication, disease severity and renal or hepatic function.
- Refer to the approved prescribing information for exact dose, frequency, route and duration of therapy.
- Do not exceed the prescribed dose, and complete the full course as advised.
- Dose adjustment may be required in renal or hepatic impairment, in the elderly and in paediatric patients.
- To be dispensed only against a valid prescription from a registered medical practitioner.
Side Effects
- Swelling of legs and ankles (peripheral oedema)
- Nasal congestion or sinusitis
- Headache and flushing
- Muscle aches and back pain
Contraindications
- Known hypersensitivity to any component of the formulation
- Pregnancy: contraindicated (birth defects); reliable contraception and pregnancy tests required
- Idiopathic pulmonary fibrosis
- Never combine with nitrates or riociguat; severe hypotension risk
- Sudden loss of vision or hearing: stop and seek urgent care
Storage
Store below 30 °C in a dry place, protected from light and moisture. Keep in the original packaging until use. Keep out of reach of children. Dispense strictly on a registered medical practitioner's prescription.
PCD Pharma Franchise & Third Party Manufacturing — Ambrisentan + Tadalafil Kit
- ✓ WHO-GMP certified manufacturing — every batch QC released
- ✓ Monopoly PCD franchise rights at district or state level
- ✓ Third party / contract manufacturing under your own brand
- ✓ Wholesale and distributor supply against drug licence + GST
- ✓ Attractive net rates with healthy PTR / PTS margins
- ✓ Dispatch within 48 hours of payment realisation
Composition: Ambrisentan 5 mg + Tadalafil 20 mg. It is a fixed-dose combination of endothelin receptor antagonist and PDE-5 inhibitor, used for pulmonary arterial hypertension (WHO Group 1) to improve exercise capacity and initial combination therapy with ambrisentan in PAH. Trumac Healthcare supplies it with complete quality documentation — batch Certificate of Analysis, GMP certificate and statutory invoicing — to PCD franchise partners, stockists, wholesalers and hospital supply chains nationwide.
Ambrisentan + Tadalafil Kit brings together Ambrisentan (endothelin receptor antagonist) and Tadalafil (PDE-5 inhibitor) in a single fixed-dose formulation.
PCD franchise partners receive monopoly territory rights at district or state level, promotional support including visual aids and sample literature, competitive net rates with healthy PTR/PTS margins, and dispatch within 48 hours of payment realisation. Third party manufacturing of Ambrisentan + Tadalafil Kit under your own brand name is available subject to minimum order quantity and valid drug licence and GST documentation.
Frequently Asked Questions
Who manufactures Ambrisentan + Tadalafil Kit in India?
Trumac Healthcare is a WHO-GMP certified manufacturer and supplier of Ambrisentan + Tadalafil Kit in India. We supply pan-India to PCD franchise partners, wholesalers, distributors and hospital chains, with full QC documentation and batch Certificate of Analysis. Contact +91 90416 77932 for net rates and availability.
What is Ambrisentan + Tadalafil Kit used for?
Ambrisentan + Tadalafil Kit is used for pulmonary arterial hypertension (WHO Group 1) to improve exercise capacity; initial combination with tadalafil to delay disease progression in PAH; initial combination therapy with ambrisentan in PAH. It should be used as advised by a registered medical practitioner.
Is Ambrisentan + Tadalafil Kit available for PCD pharma franchise on monopoly basis?
Yes. Ambrisentan 5 mg + Tadalafil 20 mg Kit is available for monopoly PCD (Propaganda Cum Distribution) pharma franchise across India, with monopoly rights granted at district or state level. Franchise partners receive promotional support, territory protection, competitive net rates with healthy PTR/PTS margins and dedicated backend support.
Do you offer Ambrisentan + Tadalafil for third party or contract manufacturing?
Yes. Trumac Healthcare undertakes third party manufacturing and contract manufacturing of Ambrisentan + Tadalafil Kit under your own brand name, subject to minimum order quantity and valid drug licence and GST documentation. Custom pack sizes, carton design and artwork are supported.
Can Ambrisentan + Tadalafil Kit be supplied on wholesale or distributor basis?
Yes. Beyond PCD franchise, this product is supplied to wholesalers, stockists and distributors at wholesale rates against a valid drug licence and GST registration. Bulk and institutional supply is available on request.
What is the therapeutic class of Ambrisentan + Tadalafil?
Ambrisentan + Tadalafil is a fixed-dose combination of endothelin receptor antagonist and PDE-5 inhibitor (therapeutic class: Fixed-Dose Combination — Endothelin receptor antagonist + PDE-5 inhibitor).
What documentation is provided with each supply?
Every batch ships with a Certificate of Analysis (COA), GMP certificate, drug licence copies and statutory invoice. We also support PCD partner documentation including monopoly agreement, rate contract and product list.
How quickly can an order be dispatched?
Routine PCD orders are dispatched within 48 hours of payment realisation, subject to stock availability and your distance from our depot. For monopoly partners we maintain buffer stock against forecasted monthly off-take.
Is a prescription required for Ambrisentan + Tadalafil Kit?
Yes. This is a prescription medicine and must be used strictly under the supervision of a registered medical practitioner. PCD franchise distribution is through licensed retail pharmacies and hospital supply chains only.
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