GLUCIM-M1 FORTE (SR)
(Glimepiride 1mg Metformin 1000mg Tablets Manufacturers Suppliers)
Trumac Healthcare is one of the leading Glimepiride 1mg Metformin 1000mg tablets manufacturers suppliers all over India.
Composition
Each Uncoated Bilayered Tablet (Sustained Release) contains:
Glimepiride I.P 1mg
Metformin HCL I.P 1000mg
(As Sustained Release)
MRP
68/- per strip
PACKING
10 x 10 (Blister)
GLIMEPIRIDE
Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose.
METFORMIN
Metformin is a biguanide which works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body’s sensitivity to insulin.
GLIMEPIRIDE
Glimepiride is a sulphonylurea antihyperglycemic agent that may be given in a single daily dose. It acts by stimulating insulin release from pancreatic beta-cells and possibly also via extrapancreatic mechanisms. The major site of activity of Glimepiride is thought to be membrane receptors on pancreatic beta-cells, where it acts via ATP-regulated potassium (KATP) channels, resulting in membrane depolarisation and release of insulin. Glimepiride is also internalised into pancreatic beta-cells, where it associates with secretory granules. This internalisation is thought to reflect insulinotropic mechanisms of Glimepiride other than at potassium channels. Glimepiride decreases blood glucose and increases blood insulin levels, with maximum effects during the first 4 hours after the dose.
METFORMIN
Metformin is a biguanide with antihyperglycemic effects, lowering both basal and postprandial plasma glucose. It does not stimulate insulin secretion and therefore does not produce hypoglycemia.
Pharmacokinetics
GLIMEPIRIDE:
Absorption:
Bioavailability is 100%. Cmax is about 103 to 591 ng/mL (dose dependent). T max is about 2 to 3 h.
Distribution:
Vd is 8.8 L. Protein binding is more than 99.5%.
Metabolism:
Completely metabolized by oxidation via CYP-450 2C9. Major metabolites are cyclohexylhydroxymethyl (M1) (about one-third of the activity of the parent) and carboxyl (M2) derivatives.
Excretion:
About 60% is excreted in urine and about 40% in feces as metabolites. The half-life is about 5 to 9.2 h.
METFORMIN:
Absorption:
After an oral dose of metformin, time to peak plasma concentration (Tmax) is reached in 2.5 hours. Absolute bioavailability of a 500 mg metformin tablet is approximately 50% to 60% in healthy subjects. Food decreases the extent of absorption and slightly delays absorption.
Distribution:
Plasma protein binding is negligible. Metformin partitions into erythrocytes. The blood peak is lower than the plasma peak and appears approximately the same time. The red blood cells most likely represent a secondary compartment of distribution. The mean Vd ranges between 63 to 276 L.
Metabolism:
Metformin is excreted unchanged in urine. No metabolites have been identified in humans.
Elimination:
Renal clearance of metformin is >400 ml/min, indicating that metformin is eliminated by glomerular filtration and tubular secretion. Following an oral dose, the apparent terminal elimination half-life is approximately 6.5 hours. When renal function is impaired, renal clearance is decreased in proportion to that of creatinine and thus the elimination half-life is prolonged, leading to increased levels of metformin in plasma.
THIRD PARTY MANUFACTURING
Apart from Glimepiride 1mg Metformin 1000mg tablets manufacturers suppliers, we at Trumac Healthcare provide range of other products across several divisions. Our product range includes:
- Dermatology
- Gynaecology
- Antibiotics
- Paediatric
- Orthopaedic
- Ayurvedic
- Cardiac Diabetic
- Injectables
- Ophthalmic
You can view our full product range below:
Contract Manufacturing
Trumac Healthcare is an ISO 9001:2015, WHO:GMP, GLP Certified Pharma Company in Chandigarh offering more than 2000+ high quality Medical Products.
We have our own manufacturing unit with sections like Injectable, Tablets, Capsules, Soft Gelatin Capsules, Oral Liquid (Syrup & Suspension), Oral Dry Syrup, External Liquids, Ointments, Creams, Betalactum Products, General Products , Nutraceuticals, Soaps, Shampoo, Eye Drops, Ear Drops , Oral Sachets & Powders , External Powder & Cosmetics.
We have 2000+ product approvals of which many are latest molecules launched in industry. We cater to all segments like Gynaecology, Dermatology, Ophthalmic, Critical Care, Paediatric, Orthopaedic, Ayurvedic, Nutraceuticals, Cosmetics, Oncology, Cardiac-Diabetic & many more.
Third Party Manufacturing & Contract Manufacturing also available.
Plant Specifications
Built up area of approx. 50,000 sq. ft with separate areas for production, stores & non process blocks.
Engineering, Utilities to commensurate production facility
Designed and built as per vertical flow concept of man – material movement
Highly skilled and experienced technical staff
Immaculate environmental monitoring, calibration and validation programme
c-GMP compliant with latest manufacturing equipments
Dedicated & modular laboratories with latest sophisticated instruments as per GLP norms
Automated access control system and fully equipped cameras
Separate entry and exit for man, material and service personnel for both process blocks
In house water & sewerage treatment plant.
Why Work with us?
Out there are many third party manufacturing facilities, so why do you have to choose us for contract manufacturing. Below are the listed advantages that we only provide in the market currently.
Online Order Tracking
In order to solve the major problem faced by many pharma clients is they are always in a state of dilemma that when their product will be dispatched. They are not able to track the lifecycle of product in a transparent manner which causes loss of trust and commitment.
We have developed a fully automatic online solution which helps you to immediately determine the production stage of products at any given time. Here are the few stages which you can see :
Design Approved
Carton/ Foil Received
Raw Material Ok & Batch Planned
Batch Processed
Testing Done
Packing Done
Dispatched from Plant
Tracking No.
100% Transparent Process
In order to give you full confidence over the quality of product we provide you with many resources such as:
COA (Certificate of Analysis)
Raw Material Procurement Certificate
Batch Inspection Report
Detailed Test Report across 15+ different parameters
With the sufficient proofs in your hand it becomes easy to convince others about the quality of your products.
New Market Opportunities
We want that our customers should always stay ahead of the competition in market. So in order to make it sure, we provide our customers with valuable market intelligence based on our 30+ years of experience in pharma industry.
Timely updates about new product launches.
Competitor Analysis
Correct MRP Guidance
Promotional Material with training
Plant Certifications
WHO:GMP Certified
At Trumac, we use state-of-the-art technology, the most stringent operating procedures and we have earned a name for ourselves for maintaining the highest standards of quality. Trumac is proud to have received the WHO:GMP certification from Health & Family Welfare Department, Himachal Pradesh.
ISO 9001:2015 Certified
ISO 9001:2015 specifies requirements for a quality management system when an organization:
a) needs to demonstrate its ability to consistently provide products and services that meet customer and applicable statutory and regulatory requirements, and
b) aims to enhance customer satisfaction through the effective application of the system, including processes for improvement of the system and the assurance of conformity to customer and applicable statutory and regulatory requirements.
Want to get your products Manufactured by us ?
We at Trumac Healthcare would be happy to help you. Just put in your details below and we will take care of everything.
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