Makclav-1.2 Injection
Amoxicillin Sodium 1000 mg + Clavulanic Acid 200 mg Injection
| Composition | Amoxicillin Sodium 1000 mg + Clavulanic Acid 200 mg |
|---|---|
| Dosage Form | Injection (Vial) |
| Pack Type | Glass Vial + Diluent |
| Pack Size | 1 Vial Pack |
| MRP | ₹ 157 |
| Therapy | Critical Care / Surgery / Infectious Disease — IV Beta-Lactam + BLI |
| Storage | Store between 2–25 °C. Use immediately after reconstitution. |
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About Makclav-1.2 Injection
Makclav-1.2 Injection delivers Amoxicillin 1000 mg + Clavulanic Acid 200 mg IV — the standard IV beta-lactam combination for hospitalised patients with severe infections, surgical prophylaxis, and infections requiring high tissue penetration.
Manufactured by Trumac Healthcare under WHO-GMP. Available for monopoly-based PCD pharma franchise and third-party manufacturing.
Indications
- Severe community-acquired pneumonia
- Surgical antibiotic prophylaxis
- Complicated UTI
- Severe skin/soft-tissue infection
- Intra-abdominal infection (adjunct)
Mechanism of Action
Amoxicillin is a beta-lactam (aminopenicillin) that binds penicillin-binding proteins (PBPs) inhibiting bacterial cell wall peptidoglycan cross-linking. Clavulanic Acid is a beta-lactamase inhibitor — irreversibly inactivates bacterial beta-lactamases protecting Amoxicillin from enzymatic hydrolysis. The combination extends Amoxicillin's spectrum to include beta-lactamase-producing strains of E. coli, H. influenzae, M. catarrhalis, and many anaerobes.
Dosage & Administration
Adults: 1.2 g IV every 8 hours (severe) or every 12 hours (moderate).
Side Effects
Diarrhoea (more common than amoxicillin alone — Clavulanate-related), GI upset, rash, candidiasis. Cholestatic hepatitis (rare). C. difficile colitis. Injection site reactions, thrombophlebitis.
Contraindications & Precautions
Penicillin/cephalosporin hypersensitivity, history of Amoxicillin-Clavulanate-induced jaundice or hepatic dysfunction, infectious mononucleosis (rash), severe renal impairment (dose adjust).
Storage
Store between 2–25 °C. Use immediately after reconstitution.
Makclav-1.2 Injection is available for monopoly-based PCD pharma franchise across India and for third-party manufacturing under your brand. WHO-GMP certified, with full visual-aid and promotional support. Become a Trumac franchise partner →
Frequently Asked Questions
What is Makclav-1.2 Injection used for?
Makclav-1.2 Injection contains Amoxicillin Sodium 1000 mg + Clavulanic Acid 200 mg. Used as per the indications described above.
How should Makclav-1.2 Injection be taken?
As directed by your physician. Complete the prescribed course.
Is Makclav-1.2 Injection available for PCD pharma franchise?
Yes, Trumac Healthcare offers Makclav-1.2 Injection on monopoly-based PCD pharma franchise and for third-party manufacturing.
How should Makclav-1.2 Injection be stored?
Store below 30 °C in a dry place, protected from light and moisture.
Is Makclav-1.2 Injection WHO-GMP certified?
Yes, manufactured in WHO-GMP and DCGI-compliant facilities.
Related Products
- Makclav-600 Injection — Amoxicillin 500 mg + Clavulanic Acid 100 mg
- Makclav-625 Tablet — Amoxycillin Trihydrate 500 mg + Potassium Clavulanate 125 mg
- Makclav-300 Injection — Amoxicillin 250 mg + Clavulanic Acid 50 mg