Amivate-25 Tablet
Amitriptyline 25 mg Tablets — Tricyclic Antidepressant for Depression & Chronic Pain
| Composition | Amitriptyline 25 mg |
|---|---|
| Dosage Form | Tablet |
| Pack Type | Blister |
| Pack Size | 10 x 10 Tablets |
| MRP | ₹ 277 |
| Therapy | Neurology + Orthopaedics + G.P. + Gynaecology — Tricyclic Antidepressant (TCA) |
| Storage | Store below 30 °C in a dry place, protected from light and moisture. |
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About Amivate-25 Tablet
Amivate-25 Tablet contains Amitriptyline Hydrochloride 25 mg — the standard mid-strength tablet used in both psychiatric and chronic pain practice. The 25 mg strength is the typical maintenance dose for chronic pain conditions and the starting dose for major depression in adults.
Like all tricyclic antidepressants, Amitriptyline blocks the reuptake of serotonin and noradrenaline, raising synaptic monoamine levels. This monoaminergic enhancement is responsible for both its antidepressant effect (over weeks) and its analgesic effect in neuropathic pain (often within days at lower doses). Its sedative profile makes the bedtime dose helpful in pain-associated insomnia.
Amivate-25 is manufactured by Trumac Healthcare under WHO-GMP conditions and is available for monopoly-based PCD pharma franchise and third-party manufacturing — a steady-volume mid-strength SKU across neurology, ortho, gynae and general practice.
Indications
- Major depressive disorder
- Painful diabetic peripheral neuropathy
- Post-herpetic neuralgia
- Fibromyalgia and chronic widespread pain
- Chronic tension headache and migraine prophylaxis
- Adjunctive use in irritable bowel syndrome with pain
Mechanism of Action
Amitriptyline non-selectively inhibits the presynaptic reuptake of serotonin and noradrenaline, raising synaptic monoamine concentrations. Additional blockade of muscarinic, histaminic and alpha-1 receptors contributes to its sedative and anticholinergic profile. In neuropathic pain, enhanced descending inhibition from brainstem nuclei dampens abnormal nociceptive transmission.
Dosage & Administration
Adults — depression: start 25 mg at bedtime, titrate weekly to 75–150 mg as tolerated. Neuropathic pain/headache prophylaxis: 25 mg at bedtime, may increase to 50–75 mg. Reduce dose in the elderly. To be prescribed by a physician.
Side Effects
Dry mouth, drowsiness, constipation, blurred vision, urinary retention, weight gain, orthostatic hypotension. At higher doses: cardiac conduction delays, QT prolongation, tachycardia. Sudden discontinuation may cause withdrawal symptoms.
Contraindications & Precautions
Hypersensitivity to TCAs. Recent myocardial infarction; cardiac arrhythmias. Concomitant MAOI use (14-day washout required). Severe hepatic impairment. Narrow-angle glaucoma. Acute mania. Caution in elderly, prostate enlargement, epilepsy.
Storage
Store below 30 °C in a dry place, protected from light and moisture.
Amivate-25 Tablet is available for monopoly-based PCD pharma franchise across India and for third-party manufacturing under your brand. WHO-GMP certified, with full visual-aid and promotional support. Become a Trumac franchise partner →
Frequently Asked Questions
What is Amivate-25 Tablet used for?
Amivate-25 Tablet contains Amitriptyline 25 mg and is used for depression, neuropathic pain (diabetic neuropathy, post-herpetic neuralgia), fibromyalgia, migraine prophylaxis and chronic tension headache.
What is the difference between Amivate-10 and Amivate-25?
Both contain Amitriptyline but at different strengths. Amivate-10 is typically used as a starting dose or for low-dose pain management; Amivate-25 is the standard maintenance dose for depression and stronger pain management.
Is Amivate-25 available for PCD pharma franchise?
Yes, Trumac Healthcare offers Amivate-25 Tablet on monopoly-based PCD pharma franchise and for third-party manufacturing.
How should Amivate-25 Tablet be stored?
Store below 30 °C in a dry place, away from direct sunlight and moisture.
Is Amivate-25 WHO-GMP certified?
Yes, Amivate-25 Tablet is manufactured in WHO-GMP and DCGI-compliant facilities.
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