Amanzil-100 Tablet
Amantadine 100 mg Tablets — Dopaminergic & Antiviral Therapy
| Composition | Amantadine 100 mg |
|---|---|
| Dosage Form | Tablet |
| Pack Type | Alu-Alu Blister |
| Pack Size | 10 x 10 Tablets |
| MRP | ₹ 1550 |
| Therapy | Neurology — Dopaminergic / NMDA Antagonist / Antiviral |
| Storage | Store below 30 °C in a dry place, protected from light and moisture. |
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About Amanzil-100 Tablet
Amanzil-100 Tablet contains Amantadine Hydrochloride 100 mg, a unique molecule that combines dopaminergic, NMDA-receptor antagonist and antiviral activity. It is used principally as adjunctive therapy in Parkinson’s disease — alone in early disease or combined with levodopa in advanced disease, where it reduces levodopa-induced dyskinesia.
Amantadine increases the release of dopamine from intact nigrostriatal terminals, inhibits dopamine reuptake and weakly antagonises NMDA glutamate receptors. The NMDA action is particularly valuable in suppressing levodopa-induced peak-dose dyskinesia, a major late-stage complication of Parkinson’s therapy. The drug also has historical activity against influenza A virus by blocking the viral M2 ion channel (though resistance is now near-universal).
Amanzil-100 is manufactured by Trumac Healthcare under WHO-GMP conditions and is available for monopoly-based PCD pharma franchise and third-party manufacturing — a steady-volume neurology SKU with strong specialist demand.
Indications
- Idiopathic Parkinson's disease (monotherapy in early disease)
- Levodopa-induced dyskinesia in advanced Parkinson's disease
- Post-encephalitic and drug-induced parkinsonism
- Multiple sclerosis-related fatigue (off-label specialist use)
Mechanism of Action
Amantadine enhances dopaminergic transmission by promoting presynaptic dopamine release, blocking dopamine reuptake, and weakly stimulating dopamine receptors. It is a non-competitive antagonist of NMDA glutamate receptors, which underlies its antidyskinetic effect by modulating overactive corticostriatal glutamatergic signalling.
Dosage & Administration
Adults: 100 mg twice daily; titrate to clinical response. Elderly and renally impaired patients: 100 mg once daily or less. Avoid late-evening doses (may cause insomnia). To be prescribed by a neurologist or physician.
Side Effects
Insomnia, nervousness, dizziness, peripheral oedema, livedo reticularis (mottled skin discolouration), dry mouth, blurred vision, constipation, urinary retention. Rarely: confusion, hallucinations (more common in elderly and renal impairment), seizures.
Contraindications & Precautions
Hypersensitivity to amantadine. Untreated narrow-angle glaucoma. Severe renal impairment. History of seizure disorder requires caution. Avoid abrupt withdrawal (risk of neuroleptic malignant syndrome-like reactions). Caution in elderly and patients with psychiatric history.
Storage
Store below 30 °C in a dry place, protected from light and moisture.
Amanzil-100 Tablet is available for monopoly-based PCD pharma franchise across India and for third-party manufacturing under your brand. WHO-GMP certified, with full visual-aid and promotional support. Become a Trumac franchise partner →
Frequently Asked Questions
What is Amanzil-100 Tablet used for?
Amanzil-100 Tablet contains Amantadine 100 mg and is used mainly for Parkinson's disease — particularly to reduce levodopa-induced dyskinesia — and historically for influenza A prophylaxis.
What is the dosage of Amanzil-100?
The usual adult dose is 100 mg twice daily; the dose is titrated to clinical response and reduced in elderly or renally impaired patients. Prescribed by a neurologist or physician.
Is Amanzil-100 available for PCD pharma franchise?
Yes, Trumac Healthcare offers Amanzil-100 Tablet on monopoly-based PCD pharma franchise and for third-party manufacturing.
How should Amanzil-100 Tablet be stored?
Store below 30 °C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Is Amanzil-100 WHO-GMP certified?
Yes, Amanzil-100 Tablet is manufactured in WHO-GMP and DCGI-compliant facilities.
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