Glibicam-Forte Tablet
Glibenclamide 5 + Metformin 500 + Pioglitazone 15 mg — Triple OAD
| Composition | Glibenclamide 5 mg + Metformin 500 mg + Pioglitazone 15 mg |
|---|---|
| Dosage Form | Tablet |
| Pack Type | Box |
| Pack Size | 10 x 10 (Blister) |
| MRP | ₹ 790 |
| Therapy | Cardiac + Diabetic — Sulphonylurea + biguanide + thiazolidinedione triple OAD |
| Storage | Store below 25°C. |
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About Glibicam-Forte Tablet
Glibicam-Forte Tablet combines three oral antidiabetic agents acting through complementary mechanisms: the sulphonylurea Glibenclamide 5 mg (stimulates pancreatic insulin secretion), the biguanide Metformin 500 mg (suppresses hepatic gluconeogenesis and improves insulin sensitivity) and the thiazolidinedione Pioglitazone 15 mg (enhances peripheral insulin sensitivity).
It is indicated in patients with type-2 diabetes mellitus inadequately controlled on dual oral therapy who require a third agent before initiating insulin or newer agents.
Camrut Healthcare manufactures Glibicam-Forte under WHO-GMP conditions for PCD pharma franchise across India.
Indications
- Type-2 diabetes uncontrolled on dual OAD
- Patients with significant insulin resistance
- Glycaemic intensification prior to insulin
Mechanism of Action
Glibenclamide closes ATP-sensitive K+ channels on pancreatic beta cells, depolarising them and triggering insulin secretion. Metformin activates AMPK and suppresses hepatic glucose output while improving peripheral insulin sensitivity. Pioglitazone activates PPAR-gamma, increasing insulin-sensitive gene expression in adipose and skeletal muscle, reducing free-fatty-acid release.
Dosage & Administration
['Adults: 1 tablet once daily before breakfast', 'Titrate based on glycaemic response', 'Monitor liver function and fluid retention', 'Use under physician supervision']
Side Effects
['Hypoglycaemia (sulphonylurea)', 'GI upset (metformin)', 'Weight gain and fluid retention (pioglitazone)', 'Bladder cancer risk with long-term pioglitazone (debated)']
Contraindications & Precautions
['Type-1 diabetes', 'Severe renal or hepatic impairment', 'Heart failure NYHA Class III–IV', 'Active bladder cancer', 'Pregnancy and breastfeeding']
Storage
Store below 25°C.
Glibicam-Forte Tablet is available for monopoly-based PCD pharma franchise across India and for third-party manufacturing under your brand. WHO-GMP certified, with full visual-aid and promotional support. Become a Trumac franchise partner →
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