Adenoset-400 Tablet
S-Adenosyl L-Methionine 400 mg Enteric-Coated Tablets — Hepatoprotective Therapy
| Composition | S-Adenosyl L-Methionine (SAMe) 400 mg |
|---|---|
| Dosage Form | Enteric-Coated Tablet |
| Pack Type | Alu-Alu Blister |
| Pack Size | 10 x 10 Tablets |
| MRP | ₹ 5990 |
| Therapy | G.P. / Hepatology / Psychiatry — Hepatoprotective / SAMe |
| Storage | Store below 25 °C in a dry place, away from light and moisture. Protect from heat. |
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About Adenoset-400 Tablet
Adenoset-400 Tablet contains S-Adenosyl L-Methionine (SAMe) 400 mg in an enteric-coated format. SAMe is a naturally occurring methyl donor synthesised in the body from methionine and ATP. It is involved in over 100 transmethylation reactions and is essential for the biosynthesis of phosphatidylcholine, glutathione and several neurotransmitters.
Clinically, Adenoset-400 is used in intrahepatic cholestasis associated with chronic liver disease and in pregnancy-related cholestasis, where it improves bile flow, reduces pruritus and normalises serum bilirubin and bile-acid levels. SAMe’s role in glutathione regeneration also gives it hepatoprotective and antioxidant properties relevant to a wide range of hepatic disorders.
Adenoset-400 is manufactured by Trumac Healthcare under WHO-GMP conditions in a specialised hepatology range. It is offered for PCD pharma franchise on a monopoly basis and for third-party manufacturing — a premium, high-margin specialty SKU for hepatology and gastroenterology focused franchises.
Indications
- Intrahepatic cholestasis in chronic liver disease (chronic hepatitis, alcoholic liver disease, primary biliary cholangitis)
- Intrahepatic cholestasis of pregnancy
- Adjuvant in liver dysfunction associated with drug-induced cholestasis
- Depressive symptoms associated with chronic liver disease (specialist supervision)
Mechanism of Action
S-Adenosyl L-Methionine is the principal methyl donor in mammalian transmethylation. It is required for the synthesis of phosphatidylcholine, a key constituent of hepatocyte membranes and bile, and for the regeneration of glutathione — the body's principal intracellular antioxidant. By restoring methylation capacity in cholestatic hepatocytes, SAMe normalises membrane fluidity, bile-acid transport and antioxidant defence.
Dosage & Administration
Adults: 400–1600 mg orally per day, divided into 1–4 doses, away from food. Treatment duration is determined by clinical response; long courses may be required in chronic liver disease. Take on an empty stomach for best absorption. Prescribe only under physician supervision.
Side Effects
Generally well tolerated. Reported effects include nausea, abdominal discomfort, diarrhoea, headache, insomnia (avoid evening dose), restlessness. Rare: serotonergic effects when combined with antidepressants.
Contraindications & Precautions
Hypersensitivity to S-Adenosyl L-Methionine. Bipolar disorder (may precipitate hypomania). Caution with concomitant serotonergic agents — SSRIs, MAOIs, tramadol, dextromethorphan — due to risk of serotonin syndrome. Avoid in active mania.
Storage
Store below 25 °C in a dry place, away from light and moisture. Protect from heat.
Adenoset-400 Tablet is available for monopoly-based PCD pharma franchise across India and for third-party manufacturing under your brand. WHO-GMP certified, with full visual-aid and promotional support. Become a Trumac franchise partner →
Frequently Asked Questions
What is Adenoset-400 Tablet used for?
Adenoset-400 Tablet contains S-Adenosyl L-Methionine 400 mg and is used for intrahepatic cholestasis in chronic liver disease and in pregnancy-related cholestasis, where it improves bile flow and reduces pruritus.
What is SAMe and how does it work?
S-Adenosyl L-Methionine (SAMe) is the body's main methyl donor. It supports hepatocyte membrane integrity by enabling phosphatidylcholine synthesis, and replenishes glutathione for antioxidant defence — making it valuable in cholestatic and oxidative liver injury.
Is Adenoset-400 available for PCD pharma franchise?
Yes, Trumac Healthcare offers Adenoset-400 on monopoly-based PCD pharma franchise as a premium hepatology SKU, and for third-party manufacturing.
How should Adenoset-400 Tablet be stored?
Store below 25 °C in a dry place, protected from light, heat and moisture. Keep the enteric coating intact — do not crush or break.
Is Adenoset-400 manufactured under WHO-GMP?
Yes, Adenoset-400 Tablet is manufactured in WHO-GMP and DCGI-compliant facilities.
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