Amiza-100 Injection
Amikacin 100 mg / 2 ml Injection — Aminoglycoside Antibiotic Therapy
| Composition | Amikacin 100 mg / 2 ml |
|---|---|
| Dosage Form | Injection (IV/IM) |
| Pack Type | Vial |
| Pack Size | 1 Vial of 2 ml (100 mg) |
| MRP | ₹ 31.9 |
| Therapy | Injectable + Antibiotic — Aminoglycoside Antibiotic |
| Storage | Store below 25 °C, protected from light. Do not freeze. |
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About Amiza-100 Injection
Amiza-100 Injection contains Amikacin Sulphate 100 mg in 2 ml, a semi-synthetic aminoglycoside antibiotic. The 100 mg strength is the standard paediatric / low-dose adult vial, commonly used for serious bacterial infections caused by gram-negative organisms — particularly hospital-acquired infections where multi-drug resistance is suspected.
Amikacin is the aminoglycoside of choice in many Indian hospitals because of its stability against most aminoglycoside-modifying enzymes that inactivate gentamicin and tobramycin. It is bactericidal against Pseudomonas aeruginosa, Klebsiella, E. coli, Proteus, Serratia, Enterobacter, Acinetobacter and atypical mycobacteria — particularly relevant in ICU and surgical units.
Amiza-100 is manufactured by Trumac Healthcare under WHO-GMP injectable-grade conditions. Available for monopoly-based PCD pharma franchise, government tenders and third-party manufacturing — a hospital staple SKU with steady institutional demand.
Indications
- Serious gram-negative bacterial infections (urinary tract, respiratory, septicaemia)
- Hospital-acquired and ventilator-associated pneumonia
- Complicated intra-abdominal infections
- Skin and soft tissue infections
- Adjunct therapy in multi-drug-resistant tuberculosis (MDR-TB)
- Empirical therapy in febrile neutropenia (with anti-pseudomonal beta-lactam)
Mechanism of Action
Amikacin binds irreversibly to the 30S bacterial ribosomal subunit, causing misreading of mRNA and inhibition of protein synthesis. The resulting production of non-functional proteins damages bacterial cell membranes and leads to rapid bactericidal effect. Aminoglycosides exhibit concentration-dependent killing and a post-antibiotic effect — supporting once-daily dosing strategies.
Dosage & Administration
Adults: 15 mg/kg/day, given as a single daily dose or in two divided doses by IM/slow IV infusion. Adjust dose in renal impairment based on serum levels. Maximum duration generally 7–10 days. Strictly under medical supervision.
Side Effects
Nephrotoxicity (acute tubular necrosis), ototoxicity (both vestibular and cochlear), neuromuscular blockade. Local injection-site pain, transient elevation of liver enzymes. Rare: hypersensitivity, rash, blood dyscrasias.
Contraindications & Precautions
Known hypersensitivity to aminoglycosides. Concomitant nephrotoxic or ototoxic drugs (furosemide, vancomycin, cisplatin, ciclosporin) without monitoring. Pre-existing 8th cranial nerve damage. Myasthenia gravis. Pregnancy (Category D — risk of fetal ototoxicity). Therapeutic drug monitoring strongly advised.
Storage
Store below 25 °C, protected from light. Do not freeze.
Amiza-100 Injection is available for monopoly-based PCD pharma franchise across India and for third-party manufacturing under your brand. WHO-GMP certified, with full visual-aid and promotional support. Become a Trumac franchise partner →
Frequently Asked Questions
What is Amiza-100 Injection used for?
Amiza-100 Injection contains Amikacin 100 mg/2 ml and is used to treat serious gram-negative bacterial infections including septicaemia, hospital-acquired pneumonia, urinary tract infections and complicated abdominal infections.
How is Amiza-100 administered?
Amiza-100 is given by intramuscular injection or slow IV infusion, calculated by body weight (15 mg/kg/day), under medical supervision. Therapeutic drug monitoring is recommended to minimise toxicity.
Is Amiza-100 available for PCD pharma franchise?
Yes, Trumac Healthcare offers Amiza-100 Injection on monopoly-based PCD pharma franchise, government tenders and third-party manufacturing.
How should Amiza-100 Injection be stored?
Store below 25 °C, protected from light. Do not freeze. Use immediately after opening.
Is Amiza-100 WHO-GMP certified?
Yes, Amiza-100 Injection is manufactured in WHO-GMP and DCGI-compliant injectable facilities.
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