Trumilast-30 Tablet

Apremilast 30 mg — PDE-4 Inhibitor

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About Trumilast-30 Tablet

Trumilast-30 Tablet contains Apremilast 30 mg, an oral selective PDE-4 inhibitor. It is the first oral non-biologic for moderate-to-severe psoriasis and psoriatic arthritis with a favourable safety profile not requiring TB screening or routine monitoring.

Indicated for moderate-to-severe plaque psoriasis, active psoriatic arthritis, oral ulcers of Behçet’s disease, and atopic dermatitis (off-label).

Camrut Healthcare manufactures Trumilast-30 under WHO-GMP conditions for PCD pharma franchise across India.

Indications

• Moderate-to-severe plaque psoriasis
• Active psoriatic arthritis
• Oral ulcers of Behçet's disease
• Atopic dermatitis (off-label)

Mechanism of Action

Apremilast selectively inhibits phosphodiesterase-4 (PDE-4), increasing intracellular cAMP in immune cells. Elevated cAMP suppresses production of TNF-α, IL-23, IL-17 and other pro-inflammatory cytokines while increasing anti-inflammatory IL-10 — modulating the psoriasis cytokine network.

Dosage & Administration

['Titrate from 10 mg over 6 days to maintenance 30 mg twice daily', 'Take with or without food', 'Reduce dose in severe renal impairment', 'Continue 4 months to assess response']

Side Effects

['GI upset (diarrhoea, nausea — most common, usually transient)', 'Headache', 'Weight loss', 'Mood disturbance and depression (boxed warning)', 'Upper respiratory infections']

Contraindications & Precautions

['Hypersensitivity to apremilast', 'Severe depression / suicidal ideation', 'Pregnancy and breastfeeding']

Storage

Store below 25°C.

Frequently Asked Questions

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