Polywise-B Injection
Polymyxin B 500,000 IU Injection — Last-Line Gram-Negative
| Composition | Polymyxin B (500,000 units) |
|---|---|
| Dosage Form | Injection (Vial) |
| Pack Type | Lyophilised Vial + Diluent |
| Pack Size | 1 Vial Pack |
| MRP | ₹ 1999 |
| Therapy | Critical Care / Infectious Disease — Cyclic Polypeptide Antibiotic |
| Storage | Store between 2–25 °C. Reconstituted: use within 24 hours refrigerated. |
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About Polywise-B Injection
Polywise-B Injection delivers Polymyxin B 500,000 units — last-line antibiotic for multi-drug-resistant gram-negative infections including carbapenem-resistant Enterobacteriaceae (CRE), Pseudomonas aeruginosa, and Acinetobacter baumannii. Reserved use due to nephrotoxicity.
Manufactured by Trumac Healthcare under WHO-GMP. Available for monopoly-based PCD pharma franchise and third-party manufacturing.
Indications
- Carbapenem-resistant Enterobacteriaceae (CRE)
- Multi-drug-resistant Pseudomonas aeruginosa
- MDR/XDR Acinetobacter baumannii
- Severe nosocomial pneumonia (resistant pathogens)
Mechanism of Action
Polymyxin B is a cyclic polypeptide antibiotic active against gram-negative bacteria — binds bacterial lipopolysaccharide (LPS) disrupting outer membrane integrity. Reserved for multi-drug-resistant gram-negative infections (Pseudomonas, Acinetobacter, KPC-producing organisms).
Dosage & Administration
Adults: 15,000–25,000 IU/kg/day in divided doses every 12 hours. Loading dose 25,000 IU/kg.
Side Effects
Nephrotoxicity (dose-dependent — monitor creatinine), neurotoxicity (paraesthesia, neuromuscular blockade), hypersensitivity, bronchospasm with nebulised use.
Contraindications & Precautions
Severe renal impairment (relative — adjust dose), myasthenia gravis (neuromuscular blockade risk), hypersensitivity.
Storage
Store between 2–25 °C. Reconstituted: use within 24 hours refrigerated.
Polywise-B Injection is available for monopoly-based PCD pharma franchise across India and for third-party manufacturing under your brand. WHO-GMP certified, with full visual-aid and promotional support. Become a Trumac franchise partner →
Frequently Asked Questions
What is Polywise-B Injection used for?
Polywise-B Injection contains Polymyxin B (500,000 units). Used as per the indications described above.
How should Polywise-B Injection be taken?
As directed by your physician. Complete the prescribed course.
Is Polywise-B Injection available for PCD pharma franchise?
Yes, Trumac Healthcare offers Polywise-B Injection on monopoly-based PCD pharma franchise and for third-party manufacturing.
How should Polywise-B Injection be stored?
Store below 30 °C in a dry place, protected from light and moisture.
Is Polywise-B Injection WHO-GMP certified?
Yes, manufactured in WHO-GMP and DCGI-compliant facilities.
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