Bilastic-40 Tablet
Bilastine 40 mg Tablets — High-Dose Non-Sedating Antihistamine for Refractory Urticaria
| Composition | Bilastine 40 mg |
|---|---|
| Dosage Form | Tablet |
| Pack Type | Alu-Alu Blister |
| Pack Size | 10 x 10 Tablets |
| MRP | ₹ 2700 |
| Therapy | Dermatology + Anti-Allergy — Second-Generation H1 Antihistamine (High Dose) |
| Storage | Store below 30 °C in a dry place, protected from light and moisture. |
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About Bilastic-40 Tablet
Bilastic-40 Tablet provides Bilastine 40 mg in a single tablet — equivalent to a double dose of standard Bilastine. The 40 mg strength is used in refractory chronic spontaneous urticaria where the 20 mg dose has been ineffective. International guidelines (EAACI/GA²LEN/EDF/WAO) endorse up-titration of second-generation antihistamines up to fourfold the standard dose before adding biologics in chronic urticaria.
Bilastine’s clean pharmacokinetic profile — no significant CYP450 metabolism, no QT prolongation, minimal CNS penetration — makes it one of the safest H1 antihistamines for dose escalation. The 40 mg dose maintains the favourable safety profile while doubling H1 receptor occupancy.
Bilastic-40 is manufactured by Trumac Healthcare under WHO-GMP conditions. Available for monopoly-based PCD pharma franchise and third-party manufacturing — a specialty derma SKU.
Indications
- Refractory chronic spontaneous urticaria (after failure of 20 mg/day)
- Severe allergic rhinitis with prominent ocular symptoms
- Dermographism not controlled by standard antihistamine dose
Mechanism of Action
Higher-dose Bilastine produces greater H1 receptor saturation, improving control of histamine-driven wheals and itch in refractory urticaria. The mechanism is the same as the standard dose — selective peripheral H1 antagonism with negligible CNS effects.
Dosage & Administration
Adults ≥ 18 years: 40 mg (one tablet) once daily for refractory urticaria, one hour before or two hours after food/fruit juice. Use only when 20 mg/day has been inadequate.
Side Effects
Headache, low rate of somnolence, dizziness, dry mouth, fatigue. Rare hypersensitivity reactions.
Contraindications & Precautions
Hypersensitivity. Concurrent fruit juices. Caution in moderate-to-severe renal impairment. Pregnancy and breastfeeding (limited data — use only if essential).
Storage
Store below 30 °C in a dry place, protected from light and moisture.
Bilastic-40 Tablet is available for monopoly-based PCD pharma franchise across India and for third-party manufacturing under your brand. WHO-GMP certified, with full visual-aid and promotional support. Become a Trumac franchise partner →
Frequently Asked Questions
What is Bilastic-40 Tablet used for?
Bilastic-40 Tablet contains Bilastine 40 mg and is used for refractory chronic urticaria when the standard 20 mg/day dose has been inadequate.
When should I move from Bilastic-20 to Bilastic-40?
After 2–4 weeks of inadequate response on Bilastic-20 daily — under physician supervision. Guideline-based up-titration is supported by international allergy/derma societies.
Is Bilastic-40 available for PCD pharma franchise?
Yes, Trumac Healthcare offers Bilastic-40 Tablet on monopoly-based PCD pharma franchise and for third-party manufacturing.
How should Bilastic-40 Tablet be stored?
Store below 30 °C in a dry place, away from direct sunlight and moisture.
Is Bilastic-40 WHO-GMP certified?
Yes, manufactured in WHO-GMP and DCGI-compliant facilities.
Related Products
- Bilastic-20 Tablet — Bilastine 20 mg
- Bilastic-AM Tablet — Bilastine 20 mg + Montelukast 10 mg + Acebrophylline 200 mg
- Bilastic-M Tablet — Bilastine 20 mg + Montelukast 10 mg