Cefiza-S Tablet
Cefixime Trihydrate 200 mg + Sulbactam 150 mg Tablets — Cefixime + Beta-Lactamase Inhibitor
| Composition | Cefixime 200 mg + Sulbactam 150 mg |
|---|---|
| Dosage Form | Tablet |
| Pack Type | Alu-Alu Blister |
| Pack Size | 10 x 10 Tablets |
| MRP | ₹ 2990 |
| Therapy | Antibiotic + G.P. + Orthopaedics — Third-Gen Cephalosporin + Beta-Lactamase Inhibitor |
| Storage | Store below 30 °C in a dry place, protected from light and moisture. |
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About Cefiza-S Tablet
Cefiza-S Tablet pairs Cefixime 200 mg with Sulbactam 150 mg — an alternative to clavulanate-based combinations for restoring activity against beta-lactamase-producing bacteria. Sulbactam is a beta-lactamase inhibitor with its own intrinsic activity against Acinetobacter species, making it particularly valuable in selected hospital-related infections.
Like cefixime+clavulanate, this combination extends spectrum to penicillinase-producing H. influenzae, M. catarrhalis, E. coli and many anaerobes. Some prescribers prefer sulbactam combinations due to lower GI side-effect profile vs clavulanate.
Cefiza-S is manufactured by Trumac Healthcare under WHO-GMP conditions. Available for monopoly-based PCD pharma franchise and third-party manufacturing — a high-value specialty antibiotic SKU.
Indications
- Acute pharyngitis and tonsillitis (streptococcal)
- Acute otitis media
- Acute exacerbations of chronic bronchitis
- Uncomplicated UTI and cystitis
- Uncomplicated gonorrhoea (single dose)
- Typhoid fever (uncomplicated)
- Beta-lactamase-producing bacterial infections
- Selected Acinetobacter infections (specialist use)
- Recurrent infections with prior antibiotic exposure
Mechanism of Action
Cefixime binds penicillin-binding proteins (PBP-3) on gram-negative bacteria, inhibiting the final transpeptidation step of peptidoglycan synthesis. The result is bacterial cell wall destabilisation and osmotic lysis. Cefixime is resistant to many beta-lactamases produced by gram-negative organisms — distinguishing it from earlier cephalosporins. Sulbactam is a competitive beta-lactamase inhibitor that prevents enzymatic destruction of cefixime, restoring activity against resistant organisms.
Dosage & Administration
Adults: 1 tablet twice daily for 5–10 days.
Side Effects
Diarrhoea (relatively common), nausea, abdominal pain, mild skin rash. Less common: hypersensitivity reactions, transient elevation of liver enzymes. Rare: pseudomembranous colitis, severe skin reactions, anaphylaxis. Generally better GI tolerance than clavulanate combinations.
Contraindications & Precautions
Hypersensitivity to cephalosporins. Severe penicillin allergy (cross-reactivity ~10%). Renal impairment requires dose adjustment. History of GI disease (caution). Hypersensitivity to sulbactam.
Storage
Store below 30 °C in a dry place, protected from light and moisture.
Cefiza-S Tablet is available for monopoly-based PCD pharma franchise across India and for third-party manufacturing under your brand. WHO-GMP certified, with full visual-aid and promotional support. Become a Trumac franchise partner →
Frequently Asked Questions
What is Cefiza-S used for?
Cefiza-S contains Cefixime 200 mg + Sulbactam 150 mg and is used for bacterial infections — UTI, ENT, respiratory tract, gastrointestinal and gynaecological infections in the appropriate age group.
How long is the course?
Typical course is 5–7 days; longer in complicated infections. Always complete the prescribed course to prevent resistance.
Is Cefiza-S available for PCD pharma franchise?
Yes, Trumac Healthcare offers Cefiza-S on monopoly-based PCD pharma franchise and for third-party manufacturing.
How should Cefiza-S be stored?
Store below 30 °C in a dry place, protected from light and moisture.
Is Cefiza-S WHO-GMP certified?
Yes, manufactured in WHO-GMP and DCGI-compliant facilities.
Related Products
- Cefiza-CV Tablet — Cefixime Trihydrate 200 mg + Clavulanic Acid 125 mg
- Cefiza-DX Tablet — Cefixime 200 mg + Dicloxacillin 500 mg (Sustained Release)
- Cefiza-O Tablet — Cefixime Trihydrate 200 mg + Ofloxacin 200 mg